For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems. Colloidal carriers like Lipospheres have been used as a physical approach to alter and improve the pharmacokinetic properties of various types of drug molecules. Lipospheres are solid microparticles composed of fat core stabilized by phospholipids layer represent promising carrier system for the delivery of highly challenging, labile and unstable substances. Lipospheres introduced in 1990 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles, it possess excellent drug delivery system and has broad prospects in the pharmaceutical field. This paper basicly reviews the types of Lipospheres, preparation, characterization and their applications in the delivery of drug molecules and therapeutic genes The future direction of research and clinical implications of Lipospheres is also considered.
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